Lee, Chang-Woo, Ph. D.


Associate Professor

Laboratory for Molecular Tumor Biology,

Department of Molecular Cell Biology,

Sungkyunkwan University School of Medicine,

Suwon 440-746, Korea.

E-mail : cwlee@med.skku.ac.kr

Phone : +82-31-299-6121

Fax : +82-31-299-6109


Education and Professional Experience

1998                 University of Glasgow/National Institute for Medical Research (UK),                         Molecular Cell Biology, Ph.D.

2000                 Harvard Medical School, Cell Biology, Postdoctoral Fellow

2005                 National Cancer Center, Research Institute, Senior Research Associate

2006~present   Sungkyunkwan University School of Medicine, Associate Professor


Selected Pubulications (Corresponding Author)

● Shin HJ, Baek KH, Jeon AH, Chung DH, Lee SJ, Lee HS, Sung YC, McKeon F, and Lee CW. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell (Cell press) 2003 4: 483-497. (IF 25.288)

● Shin HJ &Lee CW. et al. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Nature Reviews Cancer 2004 4: 91. (Highlights).

● Jeong SJ, Shin HJ, Kim SJ, Ha GH, Cho BI, Baek KH, Kim CM, Lee CW. Transcriptional abnormality of the hsMAD2 mitotic checkpoint gene is a potential link to hepatocellular carcinogenesis. Cancer Research 2004 Dec 1; 64(23): 8666-73.

● ShinHJ, Baek KH, Jeon AH, Kim SJ, Jang KL,Sung YC, Kim CM, Lee CW. Inhibitionof histone deacetylase activity increaseschromosomal instability by the aberrant regulation of mitotic checkpointactivation. Oncogene. 2003 Jun19; 22(25): 3853-8.

● Shin HJ, Park HY, Jeong SJ, Park HW, Kim YK, Cho SH, Kim YY, Cho ML, Kim HY, Min KU, Lee CW. STAT4 expression in human T cells is regulated by DNA methylation but not by promoter polymorphism. Journal of Immunology 2005 Dec 1; 175(11): 7143-50.

● Baek KH, Park HY, Kang CM, Kim SJ, Jeong SJ, Hong EK, Park JW, Sung YC, Suzuki T, Kim CM, Lee CW. Overexpression of hepatitis C virus NS5A protein induces chromosome instability via mitotic cell cycle dysregulation. Journal of Molecular Biology 2006 May 26; 359(1): 22-34.

● Ha GH, Baek KH, Kim HS, Jeong SJ, Kim CM, McKeon F, Lee CW. p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation. Cancer Research 2007 Aug 1; 67(15): 7155-64.

● Kim HS, Jeon YK, Ha GH, Park HY, Kim YJ, Shin HJ, Lee CG, Chung DH, Lee CW. Functional interaction between BubR1 and securin in an anaphase-promoting complex/cyclosomeCdc20-independent manner. Cancer Research 2009 Jan 1; 69(1): 27-36.

● Ha GH, Kim HS, Lee CG, Park HY, Kim EJ, Shin HJ, Lee JC, Lee KW, Lee CW. Mitotic catastrophe is the predominant response to histone acetyltransferase depletion. Cell Death and Differentiation 2009 Mar; 16(3): 483-97.

● Shin HJ, Lee JB, Park SH, Chang J, Lee CW. T-bet expression is regulated by EGR1 mediated signaling in activated T cells. Clinical Immunology 2009 Jun; 131(3): 385-94.

Kim HS, Baek KH, Ha GH, Lee JC, Kim YN, Lee J, Park HY, Lee NR, Lee Ho, Cho Y, and Lee CW. The hsSsu72 phosphatase is a cohesion-binding protein that regulates the resolution of sister chromatid arm cohesion. EMBO Journal 2010 Oct 20;29(20):3544-57.

Copyright ⓒ 2009 Laboratory of Molecular Tumor Biology, Department of Molecular Cell Biology

Sungkyunkwan University School of Medicine, Suwon 440-746, Korea

Phone : +82-31-299-6153 (Lab)  Fax : +82-31-299-6109